Introduction
General
Definition
Incidence
Pathogenesis
Clinical
Prevention
Management
Prognosis
References
Abbreviations
Other Lectures
|
|
Prior to the use of mechanical ventilation, babies with hyaline membrane disease (HMD) had a very high mortality rate and either died by 4-5 days of age or survived without respiratory difficulty or xray abnormality beyond 7-10 days. With the advent of modern neonatology, mortality rates in prematures plummeted, but many babies, who presumably would have previously died, began to develop more chronic respiratory symptoms. First described by Northway in 1967 in premature infants who had HMD treated with oxygen and mechanical ventilation for more than 6 days, bronchopulmonary dysplasia (BPD) has become the most common cause of chronic respiratory disease during infancy, affecting some 7000 babies per year in the U.S. It is now also the most common complication of neonatal care in babies less than 1000 grams at birth, as well as a major cause of long-term morbidity, especially pulmonary and neurodevelopmental.
|
